The Immunotherapy Of The Allergy Of The Peanut Must Be Available In Five Years
- Posted by Vernita Traynham in Uncategorized |
- May 16th, 2008 |
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Some form of immunotherapy expects to be available for allergy of the peanut inside of the five following years. But the reasons for prevalence increasing of this reaction allergic remain to unclear. The editions are argued by professor Wesley Burks, medical center of the duke University, NC, U.S.A., in a seminary in the edition of this week of lancet.
Allergy of the peanut changedded a main interest of the health worldwide, special in developed countries, and around affects 1% of the children under the age five year. It is an illness modulated for the part of immunoglobulin and the immune system - a time that the protein of the peanut ingested, it transversal linkings with these antibodies of IgE and release of the molecule causes inflammatory such as histamines. The average age of the diagnosis in the children is 14 months, with the symptoms that after occur first ingestion known of the peanut in 75% of those children who eat peanuts for the first time. Almost all the initial reactions involve the skin, respiratory, and one involve partially the interval approximately third the gastrointestinal interval.
Burks professor says: “because of the severe consequences potential of allergy of the peanut, those of the health suspected to have had a reaction allergic to the peanuts deserves a complete evaluation. All the patients with allergy of the peanut must be given a plant of the management of the emergency, as.well.as epinephrine and antihistamines to have in the hand in all the times. The patients and the families must be taught to recognize advanced reactions allergic to the peanuts and as to execute appropriate strategies of the peanut-avoidance. It is imperative that severe, or potential severe, the reactions are dealt readily with epinephrine to intramuscular and antihistamines you pray. The patients who had had such reaction must be kept under the comment in a department of the emergency of the hospital or the equivalent for up to four hours because of the possible development of the reply allergic of the late-phase.”
A study of U.S.A. he showed that prevalence of allergy of the peanut in new children doubled of 0?4% in 1997 0?8% in 2002. He has many theories regarding prevalence increased of allergy of the peanut, none of them proven. Between them it is the hypothesis of the hygiene, that that says not sufficiently exposition to the agents infectious in advanced infancy can increase susceptibility to the illness allergic. E the investigators had suggested that the presence of the peanuts in the diet of the mother before the birth could be factor of risk to develop allergy.
Between the approaches that are being looked at to reduce the impact of this circumstance is development of the plants transgenic to produce peanuts hypoallergenic. However, while diverse proteins of the peanut are involved in the reply allergic, Burks professor say: “the process to modify sufficient of allergens of the peanut to make a modified peanut that was more less probable to cause a reaction allergic would relieve probably the new peanut not longer a peanut.” The future treatments all are focused around the attempt of curb the immune reply or to induce the tolerance for the immune system in specific reply to one allergen of the food. The possible approaches include used proteins of the peanut as immunotherapy and the specific verbal induction of the tolerance projected, where the food ingested in bigger amounts each time in a regular base. Burks professor concli: “it is probable that in the five following years allergenic of the peanut will have some available type of immunotherapy for individuals.”
of “allergy peanut”
Prof A Wesley Burks MD
Lancet 2008; 371:1538-1546
DOI:10.1016/S0140-6736(08)60659-5
Estale to see in line the summary here
http://www.thelancet.com
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